We have used our unique stem cell technologies to develop cell-based therapies for significant disease conditions where the cells can be readily administered “off-the-shelf” to any eligible patient without the need for additional drug treatments. Our lead stem cell therapeutic candidate is a therapy for the treatment of patients left disabled by a stroke. We have announced positive Phase II data with this therapeutic candidate and are pursuing plans to commence a Phase IIb trial in patients who are living with disability post-stroke.
Our hRPC stem cell candidate is being developed for the treatment of retinal diseases. Clinical development of this candidate in retinitis pigmentosa, a blindness-causing disease of the retina, has commenced in the US and we are expanding our hRPC programme to target a further retinal disease, cone-rod dystrophy.
We are also progressing pre-clinical development of our exosome nanomedicine platform. Exosomes are nanoparticles secreted into the culture media during the expansion of our stem cells. They contain a number of biologically active molecules such as proteins and microRNAs (miRNAs) which are short, non-coding RNAs that can regulate gene expression. These molecules may have potential therapeutic benefits across a number of disease areas.
Our principal strategy is to gain clinical validation for our cell therapy programmes via well-designed clinical trials in well-regulated territories. Ultimately, we expect to realise value for our technologies and therapeutic programmes via out-license to commercial development partners at the appropriate points in their development. In order to achieve these objectives, we work closely with a number of key academic and industrial partners while continuing to maintain tight control over our financial resources.
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ReNeuron is incorporated in and operates primarily in the UK. Our shares are traded on the London AIM market under the symbol RENE.L