Highlights from newly released in-vivo  biodistribution and payload delivery to target tissues with CustomEXTM Exosomes

Tissue Targeting

  • A CustomEX™ exosome targets the lymph nodes (immune system) greater than other exosome types.
  • A second CustomEX™ exosome selectively targets tubules within the kidney
  • A third CustomEX™ exosome targets the lung following systemic administration

Payload Delivery

  • Delivery of a protein (BDNF) payload in vivo
  • Delivery of a small molecule payload in vivo to the lung following systemic administration
  • Up to 6 x greater delivery of an siRNA payload in vitro, when compared to siRNA alone and other exosome types

Observed effects following administration

  • No sign of immune response or toxicity with any of the exosome candidates – possible use of CustomEX™ for repeat administration unlike viral vectors.

ReNeuron continues to expand the delivery of payloads to selected tissues with engineered exosomes derived from the seven proprietary conditionally immortalised producer stem cell lines and iPSC platforms