Reneuron

1

Major Shareholdings

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The current issued share capital of the Company, including shares issued under its blocklisting facility, is 1,788,827,700 ordinary shares. No shares are held as treasury.

The Directors (together with their families and their family trusts and pension scheme arrangements) in aggregate hold 31,599,927 ordinary shares in the Company, representing 1.767% of the Company's current issued share capital.

The Company is aware of the following significant (3% or greater) shareholdings in the Company's ordinary shares:

Number of ordinary shares

% of issued share capital

Woodford Investment Management

14.87%

The Wales Life Sciences Investment Fund LP

11.18%

Invesco Limited

8.83%

Abingworth LLP

Abingworth Bioventures VI LP

5.28%

Abingworth Bioequities Master Fund Ltd

Majedie Asset Management Limited

4.94%

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