Clinical Trials

We are conducting the following clinical trials for the use of our cell therapy candidates in the potential treatment of stroke disability, critical limb ischaemia and retinitis pigmentosa.

PISCES safety study of CTX cells in the treatment of patients with stable ischaemic stroke

Clinical Trial Stage: Phase I

Trial Purpose: To test safety of CTX cells delivered by injection into the damaged brains of male patients > 60 left moderately to severely disabled 6 months to 5 years following an ischaemic stroke

Status : Study completed

Efficacy study of CTX cells in patients with stable paresis of the arm following an ischaemic stroke

Clinical Trial Stage: Phase II

Trial Purpose: To determine if treatment at a dose of 20m cells improves recovery in use of paretic arm in stroke patients to justify a larger pivotal study

Status : Data Reported

Non-interventional, observational study for patients with stable ischaemic stroke to document clinical course and establish pool of patients for on-going trials

Clinical Trial Stage: Observational

Trial Purpose: To build data set in untreated disabled stroke patients and facilitate on-going clinical trials

Next milestone: Study completed, long term follow up data H2 2017

Ascending dose safety study of CTX cells in patients with lower limb ischaemia

Clinical Trial Stage: Phase I

Trial Purpose: To investigate the safety and tolerability of intramuscular injections of CTX cells in patients with peripheral arterial disease

Next milestone: Long term safety data H1 2018

Open label prospective study of the safety and tolerability of the human retinal progenitor cell (hRPC) therapy candidate in the treatment of patients with retinitis pigmentosa

Clinical Trial Stage: Phase I/II

Trial Purpose: To evaluate the safety, tolerability and preliminary efficacy of sub-retinally transplanted hRPCs in patients with advanced retinitis pigmentosa. Dosing has commenced in the Phase II element of the study.

Next milestone: Completion of Phase II patient dosing.

Further information regarding our clinical trials, including relevant contact details, may be found on clinicaltrials.gov, a registry of clinical trials providing patients, family members, and members of the public free and easy access to information on clinical studies for a wide range of diseases and conditions: please click here.